What Is Morphine and How Does It Work?

order Morphine 60mg online uk, is used to treat severe pain. Morphine belongs to a class of drugs known as opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain. Morphine is a chemical found in the opium plant. It is a narcotic (opioid) pain-reliever similar to hydrocodone, oxycodone, methadone, fentanyl, and other opioids.

Morphine is available under the following different brand names: MS Contin, Astramorph, Depodur, Duramorph, Infumorph, Kadian, MorphaBond, and Arymo ER.

What Are Dosages of Morphine?

Dosages of Morphine

Dosage Forms and Strengths

Tablet, extended-release (MS Contin): Schedule II

15mg, 30mg, 60mg, 100mg, 200mg

Tablet, extended release (abuse-deterrent): Schedule II

15 mg, 30 mg, 60 mg (Arymo ER)
15 mg, 30 mg, 60 mg, 100 mg (MorphaBond)

Capsule, morphine sulfate extended-release: Schedule II

10 mg, 20 mg, 30 mg, 45 mg, 50 mg, 60 mg
75 mg, 80 mg, 90 mg, 100 mg, 120 mg

Capsule, extended-release (Kadian): Schedule II

10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg
70 mg, 80 mg, 100 mg, 130 mg, 150 mg, 200 mg

Injectable suspension, extended-release, liposomal (DepoDur): Schedule II

10 mg/mL

Injectable solution (Duramorph): Schedule II

0.5 mg/mL
1 mg/mL

Injectable solution, high potency (Infumorph): Schedule II

10 mg/mL (200 mg/20mL ampule)
25 mg/mL (500 mg/20mL ampule)

Morphine sulfate, injectable solution: Schedule II (adult and pediatric)

0.5 mg/mL, 1 mg/mL, 2 mg/mL, 4 mg/mL, 5 mg/mL
8 mg/mL, 10 mg/mL, 15 mg/mL, 25 mg/mL, 50 mg/mL

Tablet, morphine sulfate immediate release: Schedule II (adult and pediatric).order Morphine 60mg online uk

15 mg, 30 mg

Morphine sulfate, suppository: Schedule II

5 mg, 10 mg, 20 mg, 30 mg

Morphine sulfate, oral solution: Schedule II

10 mg/5mL; 20 mg/5mL

Morphine sulfate, intramuscular device

10 mg/0.7mL

Dosage Considerations – Should be Given as Follows:Addiction, abuse, and misuse:

Risk of opioid addiction, abuse, and misuse, which can lead to overdose and death
Assess each patient’s risk before prescribing and monitor all patients regularly for the development of these behaviors or conditions

Acute Pain

Immediate-release tablet

Opioid-naïve patients: 15-30 mg orally every 4 hours as needed

Oral solution

Opioid-naïve patients: 10-20 mg orally every 4 hours as needed

Suppository

10-20 mg PR every 4 hours

Parenteral solution

Subcutaneously/intramuscularly (SC/IM) (opioid-naïve patients): 5-10 mg every 4 hours as needed; dose range, 5-20 mg
Intravenously (IV) (opioid-naïve patients): 2.5-5 mg every 3-4 hours as needed, infused over 4-5 minutes; dose range, 4-10 mg

order Morphine 60mg online uk

Epidural injection

Single-dose: 5-10 mg once daily in the lumbar region
Continuous infusion: 2-4 mg IV infused over 24 hours
Intrathecal (IT)
- Single-dose (opioid-naive patients): 0.1-0.3 mg single dose, plus an available infusion of naloxone; dosage range per manufacturer, is 0.2-1 mg/day; because repeated IT injections are not recommended, the alternative route should be used if pain recurs within 24 hours
- Continuous infusion (opioid naive patients): 0 .2-1 mg on lumbar region over 24 hours
- Continuous infusion (opioid tolerant): 1-10 mg over 24 hours microinfusion on the lumbar region; not to exceed 20 mg over 24 hours

Extended-release liposomal injection

DepoDur treatment of pain after major surgical procedures
After cesarean section: 10 mg as a single lumbar epidural injection after the umbilical cord is clamped
Major orthopedic surgery of lower extremity: 10-15 mg as a single lumbar epidural injection before the procedure
Lower abdominal or pelvic surgery: 10-15 mg as a single lumbar epidural injection before the procedure; may benefit from 20 mg dose
Injection formulation not for intravenous (IV) administration unless opioid antagonist immediately available
The usual dosage of IV morphine in adults, regardless of indication, is 2-10 mg/70 kg body weight
Consider the lowest end of dosing range and monitor for side effects in elderly patients and those with renal or hepatic impairment
Opioid-tolerant patients may require higher initial doses; patients are considered opioid-tolerant if they take at least 60 mg/day orally of morphine, 30 mg/day orally of oxycodone, 12 mg/day orally of hydromorphone, or an equianalgesic dose of another opioid for more than 1 week
Oral solution: 100 mg/5 mL concentration is appropriate only for opioid-tolerant patients
Parenteral solution: Intramuscular (IM) injection is painful and has a variable onset of analgesia because of delayed onset of action and erratic absorption; repeated subcutaneous (SC) administration may cause local tissue damage, as well as induration, irritation, and pain at the injection site
Preservative-free parenteral solution: American Pain Society describes “ceiling” for analgesic effect with dosages greater than 0.3 mg/day and increase in adverse effects (e.g., respiratory depression); extreme caution is warranted with epidural or intrathecal (IT) administration in aged or debilitated patients, and lower dosages are usually adequate
Extended-release liposomal injectable suspension: To be administered only in a single dose via lumbar epidural route; not recommended for administration into thoracic or higher epidural spaces; not to be administered IT, IV, or IM

Chronic Severe Pain

Extended-release (ER)/long-acting (LA) formulations are indicated for the management of severe pain requiring daily, around-the-clock, long-term opioid treatment for which alternative options are inadequate

Immediate-release (IR): May also be used for management of chronic pain but require more frequent dosing; may also be used in combination with ER/LA products for breakthrough pain

The extended-release tablet (MS Contin)

Opioid-naïve patients (as first opioid dose): Initiate with 15 mg orally every 8-12 hours; use of higher starting doses in patients who are not opioid-tolerant may cause fatal respiratory depression
Opioid-tolerant patients: Dose depends on a daily dose of previous opioid analgesic (individualization required for conversion)
MS Contin dose equivalent to one-half of patient’s calculated 24-hr orally morphine requirement every 12 hours; alternatively, dose equivalent to one-third of the patient’s calculated 24-hr orally morphine requirement every 8 hours
The tablet must be swallowed whole and not broken, chewed, dissolved, or crushed; sudden release of morphine content increases the risk of respiratory depression and death.order Morphine 60mg online uk